Polti–Kometa is an Italian-registered, Spanish-based UCI ProTeam cycling team, that was founded in 2018. The team was promoted from the UCI Continental level in 2021.

The 2021 Giro d'Italia was the 104th edition of the Giro, a three-week Grand Tour cycling stage race. It started on 8 May and finished on 30 May. On 26 May 2019, the race organisers RCS Sport originally announced that the start of the 2021 Giro would be in Sicily, Italy. However, on 4 February 2021, RCS Sport announced that the race would instead start in Turin, with the rest of the race route being announced on 24 February 2021.