Polychlorinated dibenzodioxins, or simply dioxins, are a group of long-lived polyhalogenated organic compounds that are primarily anthropogenic, and contribute toxic, persistent organic pollution in t
U.S. Army Huey helicopter spraying Agent Orange over Vietnamese agricultural land
Spolana Neratovice chloralkali plant, air view
Viktor Yushchenko with chloracne after his TCDD poisoning incident
Dioxins and dioxin-like compounds are a group of chemical compounds that are persistent organic pollutants in the environment. They are mostly by-products of burning or various industrial processes or
Polychlorinated dibenzodioxins
…early as the mid 19th century during the Industrial Revolution. The word "dioxins" may also refer to other similarly acting chlorinated compounds (see Dioxins and dioxin-like compounds). The structure of dibenzo-1,4-dioxin consists of two benzene rings joined by two oxygen bridges. This makes the compound an aromatic diether. The name…
A schematic diagram of some AHR signaling pathways. The canonical pathway is depicted with solid black arrows, alternative pathways with dashed arrows, and an intersection of these two with a solid red arrow. The green bars represent the AHR, red bars ARNT, yellow bars ARA9 (AIP, Xap2), blue bars HSP90, and the blue ovals p23. Dioxin binding to the AHR (1.) leads to its translocation into the nucleus by importin-β, (2.) heterodimerization with ARNT and binding to the DNA at DREs, (3.) modulating expression levels of target genes (green arrows). One of the gene products elevated by this mechanism is AHRR, a
Decrease of dioxin concentrations in breast milk in Sweden and Finland
Decrease of dioxins in ambient air in different regions (redrawn from Dopico and Gomez, 2015)