The Ponce Historic Zone is a historic district in downtown Ponce, Puerto Rico, consisting of buildings, plazas and structures with distinctive architectures such as Neoclásico Isabelino and the Ponce Creole, a local architectural style developed between the 19th- and early 20th-centuries. The zone goes by various names, including Traditional Ponce, Central Ponce, Historic Ponce, and Ponce Historic District.

Casa Paoli is a historic house and biographical museum in barrio Cuarto, Ponce, Puerto Rico, in the Ponce Historic Zone. The house is significant as the birthplace of Antonio Paoli (1871–1946), a tenor who was the "first Puerto Rican to reach international recognition in the performing arts" and "one of the most outstanding opera singers of all times". The house was the childhood home of the artist and he was introduced to art and opera at this house during his formative years. In 1987, the house was turned into a museum to honor the career of Antonio Paoli. The building was listed on the U.S. National Register of Historic Places in 2009.