Pope Alexander VI was head of the Catholic Church and ruler of the Papal States from 11 August 1492 until his death in 1503. Born into the prominent Borgia family in Xàtiva in the Kingdom of Valencia under the Crown of Aragon, Rodrigo studied law at the University of Bologna. He was ordained deacon and made a cardinal in 1456 after the election of his uncle as Pope Callixtus III, and a year later he became vice-chancellor of the Catholic Church. He proceeded to serve in the Curia under the next four popes, acquiring significant influence and wealth in the process. In 1492, Rodrigo was elected pope, taking the name Alexander VI.

The Papal States, officially the State of the Church, were a conglomeration of territories on the Apennine Peninsula under the direct sovereign rule of the Pope from 756 until 1870. They were among the major states of Italy from the 8th century until the Unification of Italy, between 1859 and 1870.