Pope Anastasius II was the bishop of Rome from 24 November 496 to his death. He was an important figure in trying to end the Acacian schism, but his efforts resulted in the Laurentian schism, which followed his death. Anastasius was born in Rome, the son of a priest, and is buried in St. Peter's Basilica.

Pope Symmachus was the bishop of Rome from 22 November 498 to his death. His tenure was marked by a serious schism over who was elected pope by a majority of the Roman clergy.