Pope John VII was the bishop of Rome from 1 March 705 to his death. He was an ethnic Greek, one of the Byzantine popes, but had better relations with the Lombards, who ruled much of Italy, than with Emperor Justinian II, who ruled the rest.

Justinian II, nicknamed "the Slit-Nosed", was the last Byzantine emperor of the Heraclian dynasty, reigning from 685 to 695 and again from 705 to 711. Like his namesake, Justinian I, Justinian II was an ambitious and passionate ruler who was keen to restore the Roman Empire to its former glories. However, he responded brutally to any opposition to his will and lacked the finesse of his father, Constantine IV. Consequently, he generated enormous opposition to his reign, resulting in his deposition in 695 in a popular uprising. He only returned to the throne in 705 with the help of a Bulgar and Slav army. His second reign was even more despotic than the first, and in 711 he was killed by mutinous soldiers.