Pope Leo X was head of the Catholic Church and ruler of the Papal States from 9 March 1513 to his death, in December 1521.

The Republic of Florence, known officially as the Florentine Republic, was a medieval and early modern state that was centered on the Italian city of Florence in Tuscany, Italy. The republic originated in 1115, when the Florentine people rebelled against the Margraviate of Tuscany upon the death of Matilda of Tuscany, who controlled vast territories that included Florence. The Florentines formed a commune in her successors' place. The republic was ruled by a council known as the Signoria of Florence. The signoria was chosen by the gonfaloniere, who was elected every two months by Florentine guild members.