Pope Silverius was bishop of Rome from 8 June 536 to his deposition in 537, a few months before his death. His rapid rise to prominence from a deacon to the papacy coincided with the efforts of Ostrogothic king Theodahad, who intended to install a pro-Gothic candidate just before the Gothic War. Later deposed by Byzantine general Belisarius, he was tried and sent to exile on the desolated island of Palmarola, where he starved to death in 537.

Pope Hormisdas was the bishop of Rome from 20 July 514 to his death. His papacy was dominated by the Acacian schism, started in 484 by Acacius of Constantinople's efforts to placate the Monophysites. His efforts to resolve this schism were successful, and on 28 March 519, the reunion between Constantinople and Rome was ratified in the cathedral of Constantinople before a large crowd.