Popotla is a station on Line 2 of the Mexico City Metro system. It is located in the Colonia Popotla neighborhood of the Miguel Hidalgo borough of Mexico City, northwest of the city center, on the Calzada México-Tacuba. In 2019 the station had an average ridership of 10,000 passengers per day, making it the least used station on Line 2.

Line 2 is one of the 12 lines of the Mexico City Metro.