Port Byron is a village in Rock Island County, Illinois, United States and part of the Quad Cities Metropolitan Area. The population was 1,668 at the time of the 2020 census; up from 1,647 at the 2010 census.

Rock Island County is a county located in the U.S. state of Illinois, bounded on the west by the Mississippi River. According to the 2020 census, it had a population of 144,672. Its county seat is Rock Island; its largest city is neighboring Moline. Rock Island County is one of the four counties that make up the Davenport-Moline-Rock Island, IA-IL Metropolitan Statistical Area.