Port Deposit is a town in Cecil County, Maryland, United States. It is located on the east bank of the Susquehanna River near its discharge into the Chesapeake Bay. The population was 653 at the 2010 census.

Jacob Tome was an American banker, philanthropist, and politician who died as one of the richest men in the United States. He was the first millionaire of Cecil County, Maryland, and an accomplished philanthropist, giving money to colleges, churches, and schools, including establishing the Tome School.