Ellen Street railway station was the second of six stations that operated successively between 1875 and the early 2010s to serve the rural maritime town of Port Pirie, 216 km (134 mi) by rail north of Adelaide, South Australia. Soon after construction of the line towards Gladstone began in 1875, an impromptu passenger service commenced. The inaugural station, Port Pirie South, was 800 metres from the centre of the town. Since two tracks had already been laid down the middle of Ellen Street to the wharves, a small corrugated iron shed was erected as a ticket and parcels office. The street-side location was unusual for the South Australian Railways. In 1902, when passenger traffic had increased greatly, a stone building was erected in a striking Victorian Pavilion style. After the tracks were removed in 1967 and the station closed, the building's design assured its retention as a museum of the National Trust of South Australia.

Port Pirie is a small city on the east coast of the Spencer Gulf in South Australia, 223 km (139 mi) north of the state capital, Adelaide. Port Pirie is the largest city and the main retail centre of the Mid North region of South Australia. The city has an expansive history which dates back to 1845. Port Pirie was the first proclaimed regional city in South Australia, and is currently the second most important and second busiest port in SA.