The Portobelo District is one of the districts that make up the Colón Province, Panama. It covers an area of 397 sq.km, and the latest official estimate of population is 10,581. The district capital is the town of Portobelo, the Spanish roadstead on the coast of Panama which replaced the original settlement of Nombre de Dios.

Colón is a province of Panama. The capital is the city of Colón. It covers an area of 4,575.5 km2, and the population is 281,956.