Postage stamps and postal history of the Canal Zone is a subject that covers the postal system, postage stamps used and mail sent to and from the Panama Canal Zone from 1904 up until October 1978, after the United States relinquished its authority of the Zone in compliance with the treaty it reached with Panama.

The Isthmus of Panama, also historically known as the Isthmus of Darien, is the narrow strip of land that lies between the Caribbean Sea and the Pacific Ocean, linking North and South America. It contains the country of Panama and the Panama Canal. Like many isthmuses, it is a location of great geopolitical and strategic importance.