Potosí, known as Villa Imperial de Potosí in the colonial period, is the capital city and a municipality of the Department of Potosí in Bolivia. It is one of the highest cities in the world at a nominal 4,090 m (13,420 ft). For centuries, it was the location of the Spanish colonial silver mint. A considerable amount of the city's colonial architecture has been preserved in the historic center of the city, which—along with the globally important Cerro Rico de Potosí—are part of a designated UNESCO World Heritage Site.

Potosí is a department in southwestern Bolivia. It comprises 118,218 km2 with 823,517 inhabitants. The capital is the city of Potosí. It is mostly a barren, mountainous region with one large plateau to the west, where the largest salt flat in the world, Salar de Uyuni, is located.