Potrero is a census-designated place in the Mountain Empire area of southeastern San Diego County, California. The population was 648 at the 2020 United States census, down from 656 at the 2010 census
Potrero General Store located south of California State Route 94.
State Route 188, also known as Tecate Road, is an about two-mile state highway in the U.S. state of California that connects State Route 94 in San Diego County with the Mexico – United States border.