Potsdam Hauptbahnhof is the main station in the German city of Potsdam, capital of the state of Brandenburg. It lies on the Berlin–Magdeburg railway and was founded in 1838. However, it has had this name only since 1999. It was originally called Bahnhof Potsdam and it was called Potsdam Stadt (city) station from 1960. The station is the terminus of line S7 of the Berlin S-Bahn, which comes from Ahrensfelde. It is also connected with the central bus station, which is a transfer point between Potsdam and the southwestern region of Berlin, and has a stop on the Potsdam tram network. It is classified by Deutsche Bahn as a category 2 station.

Potsdam is the capital and largest city of the German state of Brandenburg. It is part of the Berlin/Brandenburg Metropolitan Region. Potsdam sits on the River Havel, a tributary of the Elbe, downstream of Berlin, and lies embedded in a hilly morainic landscape dotted with many lakes, around 20 of which are located within Potsdam's city limits. It lies some 25 kilometres southwest of Berlin's city centre. The name of the city and of many of its boroughs are of Slavic origin.