The Poughkeepsie Rural Cemetery is a rural cemetery located in Poughkeepsie, New York and includes the gravesites of several notable figures. It also has a crematory. The forty-four acres of land used for the cemetery were purchased by Matthew Vassar.

Poughkeepsie, officially the City of Poughkeepsie, which is separate from the Town of Poughkeepsie around it, is a city in the U.S. state of New York. It is the county seat of Dutchess County, with a 2020 census population of 31,577. Poughkeepsie is in the Hudson River Valley region, midway between the core of the New York metropolitan area and the state capital of Albany. It is a principal city of the Kiryas Joel–Poughkeepsie–Newburgh metropolitan area which belongs to the New York combined statistical area. It is served by the nearby Hudson Valley Regional Airport and Stewart International Airport in Orange County, New York.