The Poughkeepsie Savings Bank building is located at 21-23 Market Street in the city of that name in the U.S. state of New York. It was the third home of that bank, the first in the city, chartered in 1831 by William Davies, on that site. After 20 years on nearby Main Street, the bank bought one of its current lots and built. In 1870 the adjacent lot was purchased and the building expanded yet again, reopening anew two years later. In 1911 the bank's success led it to commission a completely new building from the firm of Mowbray and Uffinger, who had designed many bank buildings across the Eastern states.

Mowbray & Uffinger comprised an architectural partnership in New York City formed in 1895. Known for bank buildings and as vault engineers they designed over 400 banks in the pre-World War II era throughout the country. The principals were Louis Montayne Mowbray (1867-1921) and Justin Maximo Uffinger Sr. (1871-1948).