The Poughkeepsie Savings Bank building is located at 21-23 Market Street in the city of that name in the U.S. state of New York. It was the third home of that bank, the first in the city, chartered in 1831 by William Davies, on that site. After 20 years on nearby Main Street, the bank bought one of its current lots and built. In 1870 the adjacent lot was purchased and the building expanded yet again, reopening anew two years later. In 1911 the bank's success led it to commission a completely new building from the firm of Mowbray and Uffinger, who had designed many bank buildings across the Eastern states.

Nicola D'Ascenzo was an Italian-born American stained glass designer, painter and instructor. He is best known for creating stained glass windows for the Washington Memorial Chapel in Valley Forge, Pennsylvania; the Nipper Building in Camden, New Jersey; the Loyola Alumni Chapel of Our Lady at Loyola University Maryland; the Folger Shakespeare Library and Washington National Cathedral, both in Washington, D.C.