Powerlifting at the 2012 Summer Paralympics was held at ExCeL London from 30 August to 5 September, with a maximum of 200 athletes, competing in 20 events. According to the classification rules of the International Federation for Powerlifting athletes which cannot participate in weightlifting events because of a physical impairment affecting their legs or hips are deemed eligible to compete in powerlifting events at the Paralympics.

Siamand Rahman was an Iranian Paralympic powerlifter. He won gold medals at the 2012 Summer Paralympics in London, 2016 Summer Paralympics in Rio, and the 2010 Asian Para Games in Guangzhou. He is the current IPC Powerlifting World Record holder in the +107 kg category with a 310.0 kilograms (683.4 lb) bench press and also holds the junior world record with 290.0 kilograms (639.3 lb) and the Paralympic Championship Record with 310.0 kilograms (683.4 lb). Siamand died on 1, March 2020 due to cardiac arrest.