Powhatan is a town in Lawrence County, Arkansas, United States, along the Black River. The population was 72 at the 2010 census, up from 50 at the 2000 census.

Lawrence County is a county located in the U.S. state of Arkansas. As of the 2020 census, the population was 16,216. The county seat is Walnut Ridge. Lawrence County is Arkansas's second county, formed on January 15, 1815, and named for Captain James Lawrence who fought in the War of 1812. It is an alcohol prohibition or dry county.