Praed Street is a street in Paddington, west London, in the City of Westminster, most notable for being the location of London Paddington station. It runs south-westerly, straight from Edgware Road to Craven Road, Spring Street and Eastbourne Terrace. East of Norfolk Place, the street is one-way eastbound; westbound traffic has to use Sussex Gardens and Norfolk Place, and this includes the eight London bus routes that serve the street: the 7, 23, 27, 36, 205, N7, N27 and N205.

The Hilton London Metropole is a 1,100-room 4-star hotel and conference centre located on Edgware Road in central London. It is bounded by the Marylebone Flyover to the north, Praed Street to the south, and the Paddington Basin development to the west.