Prairie Island Indian Community is a Mdewakanton Sioux Indian reservation in Goodhue County, Minnesota, along the Mississippi River. Most of the reservation now lies within the city of Red Wing, which developed after this land was set aside.

The Mdewakanton or Mdewakantonwan are one of the sub-tribes of the Isanti (Santee) Dakota (Sioux). Their historic home is Mille Lacs Lake in central Minnesota. Together with the Wahpekute, they form the so-called Upper Council of the Dakota or Santee Sioux. Today their descendants are members of federally recognized tribes in Minnesota, South Dakota and Nebraska of the United States, and First Nations in Manitoba, Canada.