The pre-Adamite hypothesis or pre-Adamism is the theological belief that humans existed before the biblical character Adam. Pre-Adamism is therefore distinct from the conventional Abrahamic belief that Adam was the first human. "Pre-Adamite" is used as a term, both for those humans believed to exist before Adam, and for believers or proponents of this hypothesis.

Isaac La Peyrère (1596–1676), also known as Isaac de La Peyrère or Pererius, was a French-born theologian, writer, and lawyer. La Peyrère is best known as a 17th-century predecessor of the scientific racialist theory of polygenism in the form of his Pre-Adamite hypothesis, which offered a challenge to traditional Abrahamic understandings of the descent of the human races as derived from the Book of Genesis. In addition to this, La Peyrère anticipated Zionism, advocating a Jewish return to Palestine, within the context of premillennialist Messianic theology. He moved in prominent circles and was known for his connections to the Prince of Condé and the abdicated Queen Christina of Sweden. Born to a Huguenot family, possibly of Portuguese Jewish converso or Marrano heritage, La Peyrère was pressured to renounce his views and publicly converted to the Catholic Church towards the end of his life, though the sincerity of this conversion has been questioned.