Predestination, in theology, is the doctrine that all events have been willed by God, usually with reference to the eventual fate of the individual soul. Explanations of predestination often seek to address the paradox of free will, whereby God's omniscience seems incompatible with human free will. In this usage, predestination can be regarded as a form of religious determinism; and usually predeterminism, also known as theological determinism.

The argument from free will, also called the paradox of free will or theological fatalism, contends that omniscience and free will are incompatible and that any conception of God that incorporates both properties is therefore inconceivable. See the various controversies over claims of God's omniscience, in particular the critical notion of foreknowledge. These arguments are deeply concerned with the implications of predestination.