Prempeh College is a public secondary boarding school for boys located in Kumasi, the capital city of the Ashanti Region, Ghana. The school was founded in 1949 by the Asanteman traditional authority, the British Colonial Government, the Methodist Church Ghana and the Presbyterian Church of Ghana. The school is named after the King of Ashanti (Asantehene), Sir Osei Tutu Agyeman Prempeh II, who donated the land on which the school was built, and was modeled on Eton College in England.

Kumasi is a city in the Ashanti Region, and is among the largest metropolitan areas in Ghana. Kumasi is located in a rain forest region near Lake Bosomtwe, and is the commercial, industrial, and cultural capital of the historical Ashanti Empire. Kumasi is approximately 500 kilometres (300 mi) north of the Equator and 200 kilometres (100 mi) north of the Gulf of Guinea. Kumasi is alternatively known as "The Garden City" because of its many species of flowers and plants in the past. It is also called Oseikrom, after Osei Kofi Tutu I who was a king in the Ashanti empire.