Presbyterian Hospital was a New York City hospital. It was founded in 1868 and began operations in 1872. It was originally located between East 70th Street and 71st Streets and Madison and Park Avenue. The hospital expanded continuously throughout the late 19th century, adding an outpatient dispensary in 1888, a school of nursing in 1892, and additional beds and services in 1892, 1893, 1904 and 1912.

Edward Stephen Harkness was an American philanthropist. Given privately and through his family's Commonwealth Fund, Harkness' gifts to private hospitals, art museums, and educational institutions in the Northeastern United States were among the largest of the early twentieth century. He was a major benefactor to Columbia University, Yale University, Harvard University, Phillips Exeter Academy, St. Paul's School, the Metropolitan Museum of Art, and the University of St Andrews in Scotland. He was elected a member of the American Philosophical Society in 1934.