Prescott is a city in Pierce County, Wisconsin at the confluence of the St. Croix River and Mississippi River. The population was 4,258 at the 2010 census, making it the second-largest city in the county after River Falls, and the largest entirely within Pierce County.

Pierce County is a county in the U.S. state of Wisconsin. As of the 2020 census, the population was 42,212. Its county seat is Ellsworth.