The President of the Region of Murcia, is the head of government of the Spanish autonomous community of the Region of Murcia. Since 2014, no person who has been elected to two terms may be elected to a third.

The 1999 Murcian regional election was held on Sunday, 13 June 1999, to elect the 5th Regional Assembly of the autonomous community of the Region of Murcia. All 45 seats in the Regional Assembly were up for election. The election was held simultaneously with regional elections in twelve other autonomous communities and local elections all throughout Spain, as well as the 1999 European Parliament election.