Presidio San Luis de las Amarillas, now better known as Presidio of San Sabá, was founded in April 1757 near present-day Menard, Texas, United States to protect the Mission Santa Cruz de San Sabá, established at the same time. The presidio and mission were built to secure Spain's claim to the territory. They were part of the treaty recently reached with the Lipan Apaches of the area for mutual aid against enemies. The early functioning of the mission and presidio were undermined by Hasinai, also allied with the Spanish, attacking the Apaches. The mission was located three miles downstream from the presidio by request of the monks at the mission to ensure that the Spanish soldiers would not be a corrupting influence on the Lipan Apaches the monks were trying to convert to Christianity. The original presidio and mission were built out of logs.

Mission Santa Cruz de San Sabá was one of the Spanish missions in Texas. It was established in April 1757, along with the Presidio San Luis de las Amarillas, later renamed Presidio of San Sabá, in what is now Menard County. Located along the San Saba River, the mission was intended to convert members of the Lipan Apache tribe. Although no Apache ever resided at the mission, its existence convinced the Comanche that the Spanish had allied with the Comanche's mortal enemy. In 1758 the mission was destroyed by an estimated 2,000 warriors from the Comanche, Tonkawa, Yojuane, Bidai and Hasinai tribes. It was the only mission in Texas to be completely destroyed by Native Americans. The Indians did not attack the nearby presidio.