Preston railway station in Preston, Lancashire, England, is an interchange railway station on the West Coast Main Line, half-way between London Euston and Glasgow Central. It is served by Avanti West Coast, Northern Trains and TransPennine Express services, plus Caledonian Sleeper overnight services between London and Scotland. It is also served by the Calder Valley line to Leeds and York, and by branch lines to Blackpool North, Ormskirk and Colne.

The West Coast Main Line (WCML) is one of the most important railway corridors in the United Kingdom, connecting the major cities of London and Glasgow with branches to Birmingham, Manchester, Liverpool and Edinburgh. It is one of the busiest mixed-traffic railway routes in Europe, carrying a mixture of intercity rail, regional rail, commuter rail and rail freight traffic. The core route of the WCML runs from London to Glasgow for 399 miles (642 km) and was opened from 1837 to 1881. With additional lines deviating to Northampton, Birmingham, Manchester, Liverpool and Edinburgh, this totals a route mileage of 700 miles (1,127 km). The Glasgow–Edinburgh via Carstairs line connects the WCML to Edinburgh. However, the main London–Edinburgh route is the East Coast Main Line. Several sections of the WCML form part of the suburban railway systems in London, Coventry, Birmingham, Manchester, Liverpool and Glasgow, with many more smaller commuter stations, as well as providing links to more rural towns.