Prestonville is a largely residential area in the northwest of Brighton, part of the English city of Brighton and Hove. It covers a long, narrow and steeply sloping ridge of land between the Brighton Main Line and Dyke Road, two major transport corridors which run north-northwestwards from the centre of Brighton. Residential development started in the 1860s and spread northwards, further from central Brighton, over the next six decades. The area is characterised by middle-class and upper-middle-class housing in various styles, small-scale commercial development and long eastward views across the city. Two Anglican churches serve Prestonville—one at each end of the area—and there are several listed buildings.

Thomas Simpson (1825–1908) was a British architect associated with the seaside town of Brighton. As architect to the Brighton and Preston School Board and the equivalent institution in neighbouring Hove, he designed "a distinguished group of board schools" during the late 19th century, when the provision of mass education was greatly extended. Many of these schools survive and some have listed status. He also worked on five Nonconformist chapels for various Christian denominations, using a wide variety of materials and architectural styles. He was the father of Sir John William Simpson and Gilbert Murray Simpson, who both became architects.