Price's Missouri Expedition, also known as Price's Raid or Price's Missouri Raid, was an unsuccessful Confederate cavalry raid through Arkansas, Missouri, and Kansas in the Trans-Mississippi Theater of the American Civil War. Led by Confederate Major General Sterling Price, the campaign aimed to recapture Missouri and renew the Confederate initiative in the larger conflict.

At the outbreak of the American Civil War in April 1861, Kansas was the newest U.S. state, admitted just months earlier in January. The state had formally rejected slavery by popular vote and vowed to fight on the side of the Union, though ideological divisions with neighboring Missouri, a slave state, had led to violent conflict in previous years and persisted for the duration of the war.