The prime minister of Albania, officially the prime minister of the Republic of Albania, is the head of government of Albania. The office of the prime minister is a core institution in the politics of Albania formed after the Albanian declaration of independence on 28 November 1912. Since that time, the nation has navigated a dynamic political evolution spanning distinct periods, encompassing a monarchy, a communist regime and the eventual democratic order. In 1912, Ismail Qemali was inaugurated as the first prime minister of Albania, guiding the nation toward sovereignty amidst the complex conditions in the Balkans. In 1944, Enver Hoxha implemented a radical change in government, transforming Albania into an authoritarian and isolationist communist regime. In 1991, the nation transitioned into a democracy that marked a notable shift, when Fatos Nano emerged as the first post-communist prime minister of Albania.

In the executive branch, the head of government is the highest or the second-highest official of a sovereign state, a federated state, or a self-governing colony, autonomous region, or other government who often presides over a cabinet, a group of ministers or secretaries who lead executive departments.