The prime minister of the Czech Republic is the head of the government of the Czech Republic and the de facto leader and most powerful member of the executive branch.

Parliamentary elections were held in the Czech Republic on 8 and 9 October 2021. All 200 members of the Chamber of Deputies were elected, with the leader of the resulting government to become the Prime Minister of the Czech Republic. Following the 2017 parliamentary elections, the country had been ruled by a minority government consisting of ANO 2011 (ANO), led by prime minister Andrej Babiš, and the Czech Social Democratic Party (ČSSD), led by interior minister Jan Hamáček, with confidence and supply support from the Communist Party of Bohemia and Moravia (KSČM) until April 2021. The largest opposition party was the Civic Democratic Party (ODS), followed by the Czech Pirate Party. Other parties in the Chamber of Deputies included SPD, TOP 09, STAN, and KDU-ČSL.