The prime minister of Nagorno-Karabakh Republic was the head of government of the unrecognized Nagorno-Karabakh Republic between 1992 and 2017.

Artsakh, officially the Republic of Artsakh or the Republic of Nagorno-Karabakh, was a breakaway state in the South Caucasus whose territory was internationally recognised as part of Azerbaijan. Between 1991 and 2023, Artsakh controlled parts of the former Nagorno-Karabakh Autonomous Oblast of the Azerbaijani Soviet Socialist Republic, including its capital Stepanakert. It had been an enclave within Azerbaijan from the 2020 Nagorno-Karabakh war until the 2023 Azerbaijani offensive, when the Azerbaijani military took control over the remaining territory controlled by Artsakh. Its only overland access route to Armenia after the 2020 war was via the 5 km (3.1 mi) wide Lachin corridor, which was placed under the supervision of Russian peacekeeping forces.