Below is a list of prime ministers of the Netherlands Antilles from 1951 to 2010. In 2010 the position of Prime Minister of the Netherlands Antilles was abolished, together with the dissolution of the country itself.

The Netherlands Antilles was a constituent country of the Kingdom of the Netherlands. The country consisted of several island territories located in the Caribbean Sea. The islands were also informally known as the Dutch Antilles. The country came into being in 1954 as the autonomous successor of the Dutch colony of Curaçao and Dependencies. The Antilles were dissolved in 2010. The Dutch colony of Surinam, although relatively close by on the continent of South America, did not become part of the Netherlands Antilles but became a separate autonomous country in 1954. All the island territories that belonged to the Netherlands Antilles remain part of the kingdom today, although the legal status of each differs. As a group they are still commonly called the Dutch Caribbean, regardless of their legal status. People from this former territory continue to be called Antilleans in the Netherlands.