Prince George Winyah Parish Church is an Anglican church in Georgetown, South Carolina. Prince George Winyah is one of the oldest continuous congregations in South Carolina, and the church building is one of the oldest churches in continuous service in South Carolina. Prince George Winyah (Anglican) and Churchyard was named to the National Register of Historic Places on May 6, 1971.

Georgetown is the third oldest city in the U.S. state of South Carolina and the county seat of Georgetown County, in the Lowcountry. As of the 2010 census it had a population of 9,163. Located on Winyah Bay at the confluence of the Black, Great Pee Dee, Waccamaw, and Sampit rivers, Georgetown is the second largest seaport in South Carolina, handling over 960,000 tons of materials a year, while Charleston is the largest.