Prince of Wales Island is one of the islands of the Alexander Archipelago in the Alaska Panhandle. It is the fourth-largest island in the United States and the 97th-largest island in the world.

The Alexander Archipelago is a 300-mile (480 km) long archipelago in North America lying off the southeastern coast of Alaska. It contains about 1,100 islands, the tops of submerged coastal mountains that rise steeply from the Pacific Ocean. Deep channels and fjords separate the islands and cut them off from the mainland. The islands shelter the northern part of the Inside Passage as it winds its way among them.