The Prince of Wales Stakes is a Canadian Thoroughbred horse race run annually at Fort Erie Race Track in Fort Erie, Ontario. Restricted to only three-year-old horses bred in Canada, it is contested on dirt over a distance of 1+3⁄16 miles. In 1959, the Prince of Wales Stakes became the second race in the Canadian Triple Crown series. It follows the August running of the King's Plate and precedes the Breeders' Stakes in October.

Fort Erie Race Track is a horse racing facility in Fort Erie, Ontario, Canada, that opened on June 16, 1897. The racetrack is often referred to as "the border oval" because of the track's proximity to the U.S. border. Its most important race is the Prince of Wales Stakes, the second leg of the Canadian Triple Crown.