Maria Antonia of Naples and Sicily was the youngest surviving daughter of Ferdinand, King of Naples and Sicily, and Maria Carolina of Austria. As the wife of the future Ferdinand VII of Spain, then heir apparent to the Spanish throne, she held the title of Princess of Asturias. It is alleged that her mother-in-law, Maria Luisa of Parma, poisoned her, causing her death, but there is no evidence to prove this.

Ferdinand I was King of the Two Sicilies from 1816 until his death. Before that he had been, since 1759, King of Naples as Ferdinand IV and King of Sicily as Ferdinand III. He was deposed twice from the throne of Naples: once by the revolutionary Parthenopean Republic for six months in 1799, and again by a French invasion in 1806, before being restored in 1815 at the end of the Napoleonic Wars.