Priscus or Priskos was a leading Eastern Roman general during the reigns of the Byzantine emperors Maurice, Phocas and Heraclius. Priscus comes across as an effective and capable military leader, although the contemporary sources are markedly biased in his favour. Under Maurice, he distinguished himself in the campaigns against the Avars and their Slavic allies in the Balkans. Absent from the capital at the time of Maurice's overthrow and murder by Phocas, he was one of the few of Maurice's senior aides who were able to survive unharmed into the new regime, remaining in high office and even marrying the new emperor's daughter. Priscus, however, also negotiated with and assisted Heraclius in the overthrow of Phocas, and was entrusted with command against the Persians in 611–612. After the failure of this campaign, he was dismissed and tonsured. He died shortly after.

Maurice was Byzantine emperor from 582 to 602 and the last member of the Justinian dynasty. A successful general, Maurice was chosen as heir and son-in-law by his predecessor Tiberius II.