This is a list chronicling the history of professional wrestling at the Tokyo Dome. The Tokyo Dome stadium in Bunkyo, Tokyo, Japan has hosted a number of professional wrestling supercard events over the years. These events often air on pay-per-view (PPV) or are recorded for a future television broadcast. New Japan Pro-Wrestling (NJPW) is the promotion which has held the most shows at the Tokyo Dome, including the very first professional wrestling event in the Dome – Battle Satellite in Tokyo Dome on April 24, 1989. NJPW also holds their annual January 4 Tokyo Dome Show event, currently promoted under the Wrestle Kingdom name – Wrestle Kingdom is considered NJPW's biggest show of the year, their version of WrestleMania. The first January 4 show, Super Warriors in Tokyo Dome, took place in 1992 and has been held each year since then. With night two of Wrestle Kingdom 15, NJPW has held a total of 55 shows in the Tokyo Dome.

Wrestle Kingdom 15 in Tokyo Dome was a professional wrestling pay-per-view (PPV) event produced by New Japan Pro-Wrestling (NJPW). The event took place over two nights, on January 4 and 5, 2021 at the Tokyo Dome in Tokyo, Japan. It was the 30th January 4 Tokyo Dome Show and the 15th promoted under the Wrestle Kingdom name.