Programmed cell death protein 1 is a protein encoded in humans by the PDCD1 gene. PD-1 is a cell surface receptor on T cells and B cells that has a role in regulating the immune system's response to t
Figure 2. Evolution of PD-1 and its interacting molecules
PD-L1
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Programmed death-ligand 1 also known as cluster of differentiation 274 or B7 homolog 1 is a protein that in humans is encoded by the CD274 gene.
Programmed cell death protein 1
…PD-1 is a cell surface receptor that belongs to the immunoglobulin superfamily and is expressed on T cells and pro-B cells. PD-1 binds two ligands, PD-L1 and PD-L2. In a screen for genes involved in apoptosis, Yasumasa Ishida, Tasuku Honjo and colleagues at Kyoto University in 1992 discovered and named…
Binding interactions
Micrograph showing a PD-L1 positive lung adenocarcinoma. PD-L1 immunostain