Progress M-12M, identified by NASA as Progress 44P, was an uncrewed Progress spacecraft that was lost in a launch failure on 24 August 2011, at the start of a mission to resupply the International Space Station. It was the twelfth modernised Progress-M spacecraft to be launched. Manufactured by RKK Energia, the spacecraft was to have been operated by the Russian Federal Space Agency.

The Soyuz-U launch vehicle was an improved version of the original Soyuz rocket. Soyuz-U was part of the R-7 family of rockets based on the R-7 Semyorka missile. Members of this rocket family were designed by the TsSKB design bureau and constructed at the Progress factory in Samara, Russia. The first Soyuz-U flight took place on 18 May 1973, carrying as its payload Kosmos 559, a Zenit military surveillance satellite. The final flight of a Soyuz-U rocket took place on 22 February 2017, carrying Progress MS-05 to the International Space Station.