The Los Alamos Laboratory, also known as Project Y, was a secret laboratory established by the Manhattan Project and operated by the University of California during World War II. Its mission was to design and build the first atomic bombs. Robert Oppenheimer was its first director, serving from 1943 to December 1945, when he was succeeded by Norris Bradbury. In order to enable scientists to freely discuss their work while preserving security, the laboratory was located on the isolated Pajarito Plateau in Northern New Mexico. The wartime laboratory occupied buildings that had once been part of the Los Alamos Ranch School.

The Manhattan Project was a program of research and development undertaken during World War II to produce the first nuclear weapons. It was led by the United States in collaboration with the United Kingdom and Canada. From 1942 to 1946, the project was under the direction of Major General Leslie Groves of the U.S. Army Corps of Engineers. Nuclear physicist J. Robert Oppenheimer was the director of the Los Alamos Laboratory that designed the bombs. The Army program was designated the Manhattan District, as its first headquarters were in Manhattan; the name gradually superseded the official codename, Development of Substitute Materials, for the entire project. The project absorbed its earlier British counterpart, Tube Alloys. The Manhattan Project employed nearly 130,000 people at its peak and cost nearly US$2 billion, over 80 percent of which was for building and operating the plants that produced the fissile material. Research and production took place at more than 30 sites across the US, the UK, and Canada.