SUMMARY / RELATED TOPICS

Prostration

Prostration is the placement of the body in a reverentially or submissively prone position as a gesture. Prostration is distinguished from the lesser acts of bowing or kneeling by involving a part of the body above the knee touching the ground the hands. Major world religions employ prostration as an act of submissiveness or worship to a supreme being or other worshiped entity, as in the sajdah of the Islamic prayer, salat. In various cultures and traditions, prostrations are used to show respect to rulers, civil authorities and social elders or superiors, as in the Chinese kowtow or Ancient Persian proskynesis; the act has traditionally been an important part of religious and traditional rituals and ceremonies, remains in use in many cultures. Many religious institutions use prostrations to embody the lowering, submitting or relinquishing of the individual ego before a greater spiritual power or presence. In the Bahá'í Faith, prostrations are performed as a part of one of the alternatives of obligatory prayer and in the case of traveling, a prostration is performed in place of each missed obligatory prayer in addition to saying "Glorified be God, the Lord of Might and Majesty, of Grace and Bounty".

However, if unable to do so, saying "Glorified be God" is sufficient. There are specifics about where the prostration can take place including, "God hath granted you leave to prostrate yourselves on any surface, clean..." and "He condemns such practices as prostrating oneself before another person and other forms of behaviour that abase one individual in relation to another". In Buddhism, prostrations are used and the various stages of the physical movement are traditionally counted in threes and related to the Triple Gem, consisting of: the Awakened One his teaching his community of noble disciples. In addition, different schools within Buddhism use prostrations in various ways, such as the Tibetan tantric preliminary practice of a 100,000 prostrations as a means of overcoming pride. Tibetan pilgrims progress by prostrating themselves at each step moving forward as they get up, in such a way that they have lain on their face on each part of their route; each three paces involves a full prostration.

This is done round a stupa, in an arduous pilgrimage, Mount Kailash is circumnavigated by this method, which takes about four weeks to complete the 52 kilometre route. It is not unusual to see pilgrims prostrating all the way from their home to Lhasa, sometimes a distance of over 2000 km, the process taking up to two years to complete. In Christianity, the Eastern Orthodox, Roman Catholic and some Lutheran churches use full prostrations, lying flat on the floor face down, during the imposition of Holy Orders, Religious Profession and the Consecration of Virgins. Additionally, in the Roman Catholic Church at the beginning of the Good Friday Liturgy, the celebrating priest and the deacon prostrate themselves in front of the altar. Dominican practice on Good Friday services in priory churches includes prostration by all friars in the aisle of the church. In the Roman Catholic and Anglican churches, partial prostrations can be used in place of genuflections for those who are unable to genuflect.

The prostration is always performed before God, in the case of holy orders, profession or consecration the candidates prostrate themselves in front of the altar, a symbol of Christ. Lesser lit. "low bows" involving kneeling and touching the floor with the hands, but with the torso off the floor, are common in Eastern Orthodox and Eastern Catholic rites worship, are used in conjunction with the sign of the cross, at specific moments during the services and when venerating relics or icons. However, the use of prostrations is traditionally discouraged on the Lord's Day, during Paschaltide and on Great Feasts of the Lord. During Great Lent, Holy Week, prostrations are encouraged in all the Eastern Churches. Orthodox Christian will make prostrations in front of people, such as the bishop, one's spiritual father or one another when asking forgiveness Those who are physically unable to make full prostrations may instead substitute metanias. Oriental Orthodox prostrate during daily prayers. Syriac Orthodox and Malankara Orthodox Syrian Christians should prostrate during all daily prayers, except on days which the Holy Liturgy is celebrated.

Oriental Catholic rites use prostrations in a similar way as the Oriental Orthodox Churches. In Hinduism, eight-limbed and five-limbed prostrations are included in the religious ritual of puja. Worship in Hinduism involves invoking higher forces to assist in spiritual and material progress and is both a science and an art. A sense of bhakti or devotional love is invoked; this term is a central one in Hinduism. A direct translation from the Sanskrit to English is problematic. Worship takes a multitude of forms depending on community groups and language. There is a flavour of being in love with whatever object or focus of devotion. Worship is not confined t

Modern Madness

Modern Madness is the second studio album from American singer and songwriter Robert Tepper. After signing with Scotti Brothers and moving to Los Angeles in 1985, Tepper found himself in the public eye after actor/director Sylvester Stallone used Tepper's song "No Easy Way Out" in the movie Rocky IV; the track climbed to No. 22 on Billboard's Hot 100 in 1986, Tepper's debut album of the same name peaked at No. 144. However, the 1988 follow-up album Modern Madness was a commercial failure. Both No Easy Way Out and Modern Madness received little promotion from the label Scotti Bros. Records; as a result, Tepper separated from the label in protracted legal proceedings and was unable to record any new material although he would continue to write. A third album No Rest for the Wounded Heart would follow eight years in 1996; the album was recorded at One on One Studios. It was produced by Joe Chiccarelli and featured 10 original tracks. All songs were written by Tepper, except for "Don't Get Me Started" and "Daylight" which were both written by Tepper and Phil Galdston, whilst "Love Turned to Crime" was written by Tepper and Myron Grombacher.

The song "Fighting for You" is a duet. American pianist and singer-songwriter Tori Amos provided backing vocals on the album. After the disbanding of Amos' group Y Kant Tori Read, Amos decided to work with various artists as a backup vocalist while she decided her next career move. Two singles were lifted from the album. "The Unforgiven" was released as a 12" promo in America only, with a sticker label stating "Be one of "The Unforgiven". Both sides of the vinyl were the same track. A promotional music video was created for "The Unforgiven". "When You Dream of Love" was issued in America on 7" vinyl as a promotional release only, featuring the same track on both sides of the vinyl. In a March 1997 interview with Tepper by Stefan Edström for aor.nu, Tepper was responded to Edström's criticism of Modern Madness: "I've got to tell you... I agree with you, it was not a great time of my life, I was a little bit nutty at the time, you can hear it, it sounds like I'm screaming instead of singing. It was just a rough time of life right and I don't think I was in a good frame of mind to make a record.

You kind of hear it on that record, the songs aren't as good, the performances aren't as good. It was kind of experimental too, we were trying to do something else and it didn't work, and I had a lot of resistance on that record right from the beginning from my record company, they gave me a hard time, so I think there was a lot of frustration on there." The album was released via Scotti Bros. Records in America, Canada and certain places in Europe including Germany and Italy, it was issued on vinyl and cassette, whilst CD versions were released in America and Japan. The album was distributed by CBS Records Inc.. Since its release, the album remained that way for many years. In 2009, Sony/BMG re-released his first two albums digitally, Modern Madness was made available as a MP3 download on places such as iTunes and Amazon. Robert Tepper - vocals, keyboards Dann Huff, Gary Myrick, Gene Black - guitar Fernando Saunders - bass Leon Johnson - bass Kevin Savigar - keyboards Myron Grombacher - drums, percussion Tori Amos - backing vocals Carroll Sue Hill - vocals Dann Huff - arrangement Joe Chiccarelli - producer Bernard Frings, Toby Wright - assistant engineer Paul Lani - recording Randee St. Nicholas - photography Tony Lane, Nancy Donald - art direction

AKAP13

A-kinase anchor protein 13 is an protein that in humans is encoded by the AKAP13 gene. This protein is called AKAP-Lbc because it encodes the lymphocyte blast crisis oncogene, ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor domain for the RhoA small GTP-binding protein. A-kinase anchor protein 13/Rho guanine nucleotide exchange factor 13 is guanine nucleotide exchange factor for the RhoA small GTPase protein. Rho is a small GTPase protein, inactive when bound to the guanine nucleotide GDP, but when acted on by Rho GEF proteins such as AKAP13, this GDP is released and replaced by GTP, leading to the active state of Rho. In this active, GTP-bound conformation, Rho can bind to and activate specific effector proteins and enzymes to regulate cellular functions. In particular, active Rho is a major regulator of the cell actin cytoskeleton. AKAP13 is a member of a group of four RhoGEF proteins known to be activated by G protein coupled receptors coupled to the G12 and G13 heterotrimeric G proteins.

The others are ARHGEF1, ARHGEF11, ARHGEF12. GPCR-regulated AKAP13 acts as an effector for G13 G proteins. Unlike the other three members, AKAP13 does not function as RGS family GTPase-activating proteins to increase the rate of GTP hydrolysis of G12/G13 alpha proteins; the A-kinase anchor proteins are a group of structurally diverse proteins that have the common function of binding to the regulatory subunit of protein kinase A, thus confining the holoenzyme to discrete locations within the cell. The AKAP13 gene encodes a member of the AKAP family since the protein binds to PKA in the heart. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms. All three contain the Dbl oncogene homology domain plus Pleckstrin homology domain characteristic of Rho family GEFs, while only the longer two isoforms contain the AKAP domain. Therefore, these isoforms may function as scaffolding proteins to coordinate Rho signaling and protein kinase A signaling. AKAP13 has been shown to interact with: CTNNAL1 Estrogen receptor alpha GNA12 GNA13 PRKAR2A Second messenger system G protein-coupled receptor Heterotrimeric G protein Small GTPases Rho family of GTPases Protein kinase A Human AKAP13 genome location and AKAP13 gene details page in the UCSC Genome Browser.

Overview of all the structural information available in the PDB for UniProt: Q12802 at the PDBe-KB