The province of Ascoli Piceno is a province in the Marche region of Italy. Its capital is the city of Ascoli Piceno, and the province is bordered by the Adriatic Sea to the east, the province of Fermo to the north, and it faces the regions of Umbria and Abruzzo to the south. The province contains 33 comuni. The population of the province is mostly located in coastal areas and in the city of San Benedetto del Tronto, which has a population of 47,075; the province has a total population of 201,462 as of 2023.

Marche, in English sometimes referred to as the Marches, is one of the twenty regions of Italy. The region is located in the central area of the country, and has a population of about 1.5 million people, being the thirteenth largest region in the country by number of inhabitants. The region's capital and largest city is Ancona.