The province of Isernia is a province in the Molise region of Italy. The provincial capital is the city Isernia and the president of the province is Alfredo Ricci. The province of Isernia has an area of 1,535.24 square kilometres (592.76 sq mi) and a population of 86,405 inhabitants as of 2016. It contains 52 comuni in the province, listed at comuni of the province of Isernia.

Molise is a region of Southern Italy. Until 1963, it formed part of the region of Abruzzi e Molise together with Abruzzo. The split, which did not become effective until 1970, makes Molise the newest region in Italy. Covering 4,438 square kilometres (1,714 sq mi), it is the second smallest region in the country, after the Aosta Valley, and has a population of 313,348.