The Ptolemaic Kingdom or Ptolemaic Empire was an Ancient Greek polity based in Egypt during the Hellenistic period. It was founded in 305 BC by the Macedonian general Ptolemy I Soter, a companion of Alexander the Great, and ruled by the Ptolemaic dynasty until the death of Cleopatra VII in 30 BC. Reigning for nearly three centuries, the Ptolemies were the longest and final dynasty of ancient Egypt, heralding a distinctly new era for religious and cultural syncretism between Greek and Egyptian culture.

Cleopatra VII, the last ruler of Ptolemaic Egypt, died on either 10 or 12 August, 30 BC, in Alexandria, when she was 39 years old. According to popular belief, Cleopatra killed herself by allowing an asp to bite her, but according to the Roman-era writers Strabo, Plutarch, and Cassius Dio, Cleopatra poisoned herself using either a toxic ointment or by introducing the poison with a sharp implement such as a hairpin. Modern scholars debate the validity of ancient reports involving snakebites as the cause of death and whether she was murdered. Some academics hypothesize that her Roman political rival Octavian forced her to kill herself in a manner of her choosing. The location of Cleopatra's tomb is unknown. It was recorded that Octavian allowed for her and her husband, the Roman politician and general Mark Antony, who stabbed himself with a sword, to be buried together properly.